Profile of Scott J. Hultgren.

Washington University Record, April 16, 1998

Blueprinting the regulatory response of Escherichia coli to the urinary tract.

Recent work has shown how comparative genomic and microarray analyses can provide insights into the transcriptional state of uropathogenic Escherichia coli (UPEC) during infection. This study will serve as an important platform from which to identify virulence determinants and the principle mechanisms of adaptation to the urinary tract.

Syntheses and biological evaluation of 2 - amino - 3 - acyl -

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LRP6 Holds the Key to the Entry of Anthrax Toxin

In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two previously identified receptors for anthrax toxin.

Fiber assembly by the chaperone-usher pathway.

Bacterial pathogens utilize the chaperone-usher pathway to assemble extracellular multi-subunit fibers essential for virulence. The periplasmic chaperone facilitates the initial folding of fiber subunits but then traps them in activated folding transition states. Chaperone dissociation releases the folding energy that drives subunit incorporation into the fiber, which grows through a pore forme...